Bacteriologic studies of skin, tissue fluid, lymph, and lymph nodes in patients with filarial lymphedema.
Identifieur interne : 004F91 ( PubMed/Curation ); précédent : 004F90; suivant : 004F92Bacteriologic studies of skin, tissue fluid, lymph, and lymph nodes in patients with filarial lymphedema.
Auteurs : W L Olszewski ; S. Jamal ; G. Manokaran ; S. Pani ; V. Kumaraswami ; U. Kubicka ; B. Lukomska ; A. Dworczynski ; E. Swoboda ; F. Meisel-MikolajczykSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1997.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antibactériens (pharmacologie), Bactéries (), Bactéries (isolement et purification), Bactériémie (microbiologie), Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (microbiologie), Humains, Liquides biologiques (microbiologie), Lymphe (microbiologie), Mâle, Noeuds lymphatiques (microbiologie), Numération de colonies microbiennes, Peau (microbiologie), Tests de sensibilité microbienne.
- MESH :
- anatomopathologie : Filariose lymphatique.
- isolement et purification : Bactéries.
- microbiologie : Bactériémie, Filariose lymphatique, Liquides biologiques, Lymphe, Noeuds lymphatiques, Peau.
- pharmacologie : Antibactériens.
- Adolescent, Adulte, Adulte d'âge moyen, Bactéries, Femelle, Humains, Mâle, Numération de colonies microbiennes, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Adolescent, Adult, Anti-Bacterial Agents (pharmacology), Bacteremia (microbiology), Bacteria (drug effects), Bacteria (isolation & purification), Body Fluids (microbiology), Colony Count, Microbial, Elephantiasis, Filarial (microbiology), Elephantiasis, Filarial (pathology), Female, Humans, Lymph (microbiology), Lymph Nodes (microbiology), Male, Microbial Sensitivity Tests, Middle Aged, Skin (microbiology).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents.
- drug effects : Bacteria.
- isolation & purification : Bacteria.
- microbiology : Bacteremia, Body Fluids, Elephantiasis, Filarial, Lymph, Lymph Nodes, Skin.
- pathology : Elephantiasis, Filarial.
- Adolescent, Adult, Colony Count, Microbial, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged.
Abstract
Filarial lymphedema is complicated by frequent episodes of dermatolymphangioadenitis (DLA). It is not certain whether DLA is of filarial or bacterial etiology. The frequency of episodic DLA does not depend on the presence or absence of microfilariae. Antibiotic therapy is effective in prevention and treatment of DLA. These observations point to the bacterial rather than filarial etiology of DLA. Skin and lymph node biopsies, tissue fluid, lymph, and blood from patients with chronic filarial lymphedema, and during acute episodes of DLA, were cultured for detection of bacteria. A high prevalence of bacterial isolates from the tissue fluid (64%), lymph (75%), and inguinal lymph nodes (66%) of limbs with filarial lymphedema was found. Bacillus cereus, Staphylococcus epidermidis, S. hominis, S. capitis, S. xylosus, and Micrococcus spp. were the most common isolates. Bacteria were also isolated from the blood of patients with recent episodes of DLA, with strains of the same phenotype and antibiotic sensitivity in all specimens from patients with DLA. Bacterial strains of the same phenotype and antibiotic sensitivity were documented on the toe web surface and in tissue fluid (25%), lymph (26%), or lymph nodes (41%). Increasing prevalence of bacterial isolates in tissue fluid, lymph, and lymph nodes was observed in advanced stages of lymphedema. Bacilli and cocci were sensitive to gentamicin, tetracyline, rifampicin, vancomycin, kanamycin and cotrimoxazole, and least sensitive to penicillin. Blood cultures of patients in the periods between DLA attacks were negative. In healthy controls without edema and episodes of DLA, tissue fluid did not contain bacteria. In lymph, only single colonies of Micrococcus and Acinetobacter were cultured in 12% of the cases. Impaired lymph drainage and lack of elimination of penetrating bacteria may be responsible for progression of lymphedema and recurrent attacks of DLA.
PubMed: 9242310
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W L Olszewski<affiliation><nlm:affiliation>Department of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw.</nlm:affiliation><wicri:noCountry code="subField">Warsaw</wicri:noCountry></affiliation>Le document en format XML
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Jamal</name></author><author><name sortKey="Manokaran, G" sort="Manokaran, G" uniqKey="Manokaran G" first="G" last="Manokaran">G. Manokaran</name></author><author><name sortKey="Pani, S" sort="Pani, S" uniqKey="Pani S" first="S" last="Pani">S. Pani</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Kubicka, U" sort="Kubicka, U" uniqKey="Kubicka U" first="U" last="Kubicka">U. Kubicka</name></author><author><name sortKey="Lukomska, B" sort="Lukomska, B" uniqKey="Lukomska B" first="B" last="Lukomska">B. Lukomska</name></author><author><name sortKey="Dworczynski, A" sort="Dworczynski, A" uniqKey="Dworczynski A" first="A" last="Dworczynski">A. Dworczynski</name></author><author><name sortKey="Swoboda, E" sort="Swoboda, E" uniqKey="Swoboda E" first="E" last="Swoboda">E. Swoboda</name></author><author><name sortKey="Meisel Mikolajczyk, F" sort="Meisel Mikolajczyk, F" uniqKey="Meisel Mikolajczyk F" first="F" last="Meisel-Mikolajczyk">F. Meisel-Mikolajczyk</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Bacteremia (microbiology)</term><term>Bacteria (drug effects)</term><term>Bacteria (isolation & purification)</term><term>Body Fluids (microbiology)</term><term>Colony Count, Microbial</term><term>Elephantiasis, Filarial (microbiology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Female</term><term>Humans</term><term>Lymph (microbiology)</term><term>Lymph Nodes (microbiology)</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Skin (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antibactériens (pharmacologie)</term><term>Bactéries ()</term><term>Bactéries (isolement et purification)</term><term>Bactériémie (microbiologie)</term><term>Femelle</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (microbiologie)</term><term>Humains</term><term>Liquides biologiques (microbiologie)</term><term>Lymphe (microbiologie)</term><term>Mâle</term><term>Noeuds lymphatiques (microbiologie)</term><term>Numération de colonies microbiennes</term><term>Peau (microbiologie)</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bactéries</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Bactériémie</term><term>Filariose lymphatique</term><term>Liquides biologiques</term><term>Lymphe</term><term>Noeuds lymphatiques</term><term>Peau</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacteremia</term><term>Body Fluids</term><term>Elephantiasis, Filarial</term><term>Lymph</term><term>Lymph Nodes</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Colony Count, Microbial</term><term>Female</term><term>Humans</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bactéries</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Numération de colonies microbiennes</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Filarial lymphedema is complicated by frequent episodes of dermatolymphangioadenitis (DLA). It is not certain whether DLA is of filarial or bacterial etiology. The frequency of episodic DLA does not depend on the presence or absence of microfilariae. Antibiotic therapy is effective in prevention and treatment of DLA. These observations point to the bacterial rather than filarial etiology of DLA. Skin and lymph node biopsies, tissue fluid, lymph, and blood from patients with chronic filarial lymphedema, and during acute episodes of DLA, were cultured for detection of bacteria. A high prevalence of bacterial isolates from the tissue fluid (64%), lymph (75%), and inguinal lymph nodes (66%) of limbs with filarial lymphedema was found. Bacillus cereus, Staphylococcus epidermidis, S. hominis, S. capitis, S. xylosus, and Micrococcus spp. were the most common isolates. Bacteria were also isolated from the blood of patients with recent episodes of DLA, with strains of the same phenotype and antibiotic sensitivity in all specimens from patients with DLA. Bacterial strains of the same phenotype and antibiotic sensitivity were documented on the toe web surface and in tissue fluid (25%), lymph (26%), or lymph nodes (41%). Increasing prevalence of bacterial isolates in tissue fluid, lymph, and lymph nodes was observed in advanced stages of lymphedema. Bacilli and cocci were sensitive to gentamicin, tetracyline, rifampicin, vancomycin, kanamycin and cotrimoxazole, and least sensitive to penicillin. Blood cultures of patients in the periods between DLA attacks were negative. In healthy controls without edema and episodes of DLA, tissue fluid did not contain bacteria. In lymph, only single colonies of Micrococcus and Acinetobacter were cultured in 12% of the cases. Impaired lymph drainage and lack of elimination of penetrating bacteria may be responsible for progression of lymphedema and recurrent attacks of DLA.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9242310</PMID><DateCreated><Year>1997</Year><Month>08</Month><Day>12</Day></DateCreated><DateCompleted><Year>1997</Year><Month>08</Month><Day>12</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9637</ISSN><JournalIssue CitedMedium="Print"><Volume>57</Volume><Issue>1</Issue><PubDate><Year>1997</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The American journal of tropical medicine and hygiene</Title><ISOAbbreviation>Am. J. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Bacteriologic studies of skin, tissue fluid, lymph, and lymph nodes in patients with filarial lymphedema.</ArticleTitle><Pagination><MedlinePgn>7-15</MedlinePgn></Pagination><Abstract><AbstractText>Filarial lymphedema is complicated by frequent episodes of dermatolymphangioadenitis (DLA). It is not certain whether DLA is of filarial or bacterial etiology. The frequency of episodic DLA does not depend on the presence or absence of microfilariae. Antibiotic therapy is effective in prevention and treatment of DLA. These observations point to the bacterial rather than filarial etiology of DLA. Skin and lymph node biopsies, tissue fluid, lymph, and blood from patients with chronic filarial lymphedema, and during acute episodes of DLA, were cultured for detection of bacteria. A high prevalence of bacterial isolates from the tissue fluid (64%), lymph (75%), and inguinal lymph nodes (66%) of limbs with filarial lymphedema was found. Bacillus cereus, Staphylococcus epidermidis, S. hominis, S. capitis, S. xylosus, and Micrococcus spp. were the most common isolates. Bacteria were also isolated from the blood of patients with recent episodes of DLA, with strains of the same phenotype and antibiotic sensitivity in all specimens from patients with DLA. Bacterial strains of the same phenotype and antibiotic sensitivity were documented on the toe web surface and in tissue fluid (25%), lymph (26%), or lymph nodes (41%). Increasing prevalence of bacterial isolates in tissue fluid, lymph, and lymph nodes was observed in advanced stages of lymphedema. Bacilli and cocci were sensitive to gentamicin, tetracyline, rifampicin, vancomycin, kanamycin and cotrimoxazole, and least sensitive to penicillin. Blood cultures of patients in the periods between DLA attacks were negative. In healthy controls without edema and episodes of DLA, tissue fluid did not contain bacteria. In lymph, only single colonies of Micrococcus and Acinetobacter were cultured in 12% of the cases. Impaired lymph drainage and lack of elimination of penetrating bacteria may be responsible for progression of lymphedema and recurrent attacks of DLA.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Olszewski</LastName><ForeName>W L</ForeName><Initials>WL</Initials><AffiliationInfo><Affiliation>Department of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamal</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Manokaran</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Pani</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kumaraswami</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Kubicka</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Lukomska</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Dworczynski</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Swoboda</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Meisel-Mikolajczyk</LastName><ForeName>F</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Trop Med Hyg</MedlineTA><NlmUniqueID>0370507</NlmUniqueID><ISSNLinking>0002-9637</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016470" MajorTopicYN="N">Bacteremia</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001826" MajorTopicYN="N">Body Fluids</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015169" MajorTopicYN="N">Colony Count, Microbial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008196" MajorTopicYN="N">Lymph</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008198" MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>7</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>7</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9242310</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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